An Explainable Artificial Intelligence Approach for Early Disease Prediction and Risk Assessment Using Healthcare Big Data

Authors

  • Dr. Nidhi Srivastava Professor , MSOPS, Maharishi University of Information Technology, Lucknow, Uttar Pradesh, India.
  • Dr. Soumya Surath Panda Professor, Department of Onco-Medicine, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.
  • Dr. Vijay J. Upadhye Associate Professor, Parul Institute of Applied Scienes ,Parul University, PO Limda, Tal. Waghodia, District Vadodara, Gujarat, India.
  • Sunil Thakur School of Engineering & Technology, Noida international University, Uttar Pradesh, India.
  • Shailesh Kulkarni Professor, Department of E&TC Engineering, Vishwakarma Institute of Technology, Pune, Maharashtra, 411037.
  • Shanthi R Department of Mathematics, Assistant Professor & HOD, Meenakshi College of Arts and Science, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.
  • Malarvizhi S Department of Commerce, Assistant Professor, Meenakshi College of Arts and Science, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.
  • Monisha J Department of Management Studies, Assistant Professor, Meenakshi College of Arts and Science, Meenakshi Academy of Higher Education and Research, Chennai, Tamil Nadu, India.

Keywords:

Explainable Artificial Intelligence, Early Disease Prediction, Healthcare Big Data, Intelligent Risk Assessment, Clinical Decision Support Systems, Healthcare Analytics, Personalized Healthcare, Disease Classification.

Abstract

The swift development of healthcare big data produced by electronic health records, wearable sensors, laboratory reports, and medical imaging systems has created strong prospects in predicting diseases earlier. Nonetheless, the current artificial intelligence designs tend to have low interpretability, low clinical trust, and low performance when applied to heterogeneous and high-dimensional healthcare data. Specifically, the black-box methods of deep learning do not offer clear explanations of disease predictions and, thus, cannot be adopted in real-life clinical settings. To overcome these issues, this paper suggests an Explainable Artificial Intelligence (XAI)-based method of early disease prediction and smart risk assessment with the help of healthcare big data analytics. To enhance transparency, interpretability, and clinician confidence, the proposed system will combine state-of-the-art machine learning models with the explainability algorithms of SHAP and LIME. Hybrid predictive architecture that combines XGBoost and deep neural networks are used to analyze large patient data and categorize patients as low-, medium- and high-risk. Experimental analysis with benchmark healthcare data reveals that the recommended framework obtains a 96.2% prediction accuracy, a 95.1% precision, a 94.6% recall, and a 95.8% F1-score, which is superior to traditional machine learning techniques. Also, the explainability layer enhances greatly clinical interpretability and aids sound decision-making in proactive and personalized healthcare management.

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Published

2026-05-12

How to Cite

Srivastava , D. N., Panda, D. S. S., Upadhye, D. V. J., Thakur, S., Kulkarni, S., R, S., … J, M. (2026). An Explainable Artificial Intelligence Approach for Early Disease Prediction and Risk Assessment Using Healthcare Big Data. International Journal of Artificial Intelligence and Machine Learning, 6(2s), 344–353. Retrieved from https://www.svedbergopen.com/index.php/ijaiml/article/view/211

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